(Z) -Guggulsterone

(Z) -Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z) -Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1]. (Z) -Guggulsterone is also a potent FXR antagonist. (Z) -Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection[2].

Product Specifications

CAS Number

[39025-23-5]

UNSPSC

12352211

Hazard Statement

H335

Target

Akt; Angiotensin-converting Enzyme (ACE) ; Apoptosis; FXR; SARS-CoV; VEGFR

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/z-guggulsterone.html

Purity

99.41

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1.[Z]

Molecular Formula

C21H28O2

Molecular Weight

312.45

Precautions

H335

References & Citations

[1]Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7 (1) :171-80.|[2]Brevini T, et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022 Dec 5.