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K114

K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI) [2].

Product Specifications

CAS Number

[872201-12-2]

UNSPSC

12171500

Hazard Statement

H319-H413

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/k114.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

BrC1=CC(/C=C/C2=CC=C(O)C=C2)=CC=C1/C=C/C3=CC=C(O)C=C3

Molecular Formula

C22H17BrO2

Molecular Weight

393.27

Precautions

P264-P273-P280-P305+P351+P338-P501

References & Citations

[1]LeVine H 3rd, et al. Mechanism of A beta (1-40) fibril-induced fluorescence of (trans, trans) -1-bromo-2,5-bis (4-hydroxystyryl) benzene (K114) . Biochemistry. 2005 Dec 6;44 (48) :15937-43.|[2]Selmani V, et al. K114 (trans, trans) -bromo-2,5-bis (4-hydroxystyryl) benzene is an efficient detector of cationic amyloid fibrils. Protein Sci. 2015 Mar;24 (3) :420-5.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-103470/K114-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-103470/K114-SDS-MedChemExpress.pdf

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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