Taurolidine

Taurolidine is a potent antimicrobial and anticancer agent. Taurolidine inhibits cell proliferation. Taurolidine induces apoptosis and autophagy. Taurolidine rescues mice from sepsis-associated lethality[1][2].

Product Specifications

CAS Number

[19388-87-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Antibiotic; Apoptosis; Autophagy; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/taurolidine.html

Purity

98.19

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=S1(NCN(CN(CC2)CNS2(=O)=O)CC1)=O

Molecular Formula

C7H16N4O4S2

Molecular Weight

284.36

Precautions

H315, H319, H335

References & Citations

[1]Marley K, et al. The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro. BMC Vet Res. 2013 Jan 18;9:15. doi: 10.1186/1746-6148-9-15.|[2]Huang J, et al. Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance. Proc Natl Acad Sci U S A. 2022 May 10;119 (19) :e2121244119.