PI3Kδ-IN-20

PI3Kδ-IN-20 (compound (S) -36) is a potent inhibitor of PI3Kδ, with the IC50 of 6.4 nM. PI3Kδ-IN-20 has oral bioactivity. PI3Kδ-IN-20 shows significant suppression of cell proliferation and remarkable induction of apoptosis both in vitro and in vivo[1].

Product Specifications

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3kδ-in-20.html

Solubility

10 mM in DMSO

Smiles

CC1=NN([C@H](C2=NN(C3=CC(Cl)=CC=C23)C4=CC=NC=C4)C)C5=C1C(N)=NC=N5

Molecular Formula

C20H17ClN8

Molecular Weight

404.86

References & Citations

[1]Yongmei Tang, et al. Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2024 Apr 25;67 (8) :6638-6657.