Docosahexaenoyl serotonin

Docosahexaenoyl serotonin (DHA-5-HT) is an endogenous n-3 fatty acid-serotonin conjugate. Docosahexaenoyl serotonin is an inhibitor of IL-17. Docosahexaenoyl serotonin has anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[283601-58-1]

Product Name Alternative

DHA-5-HT

UNSPSC

12352005

Hazard Statement

H225, H350

Target

Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/docosahexaenoyl-serotonin.html

Concentration

20.55 mM * 500 μL in Ethanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCC1=CNC2=C1C=C(O)C=C2)=O

Molecular Formula

C32H42N2O2

Molecular Weight

486.69

Precautions

H225, H350

References & Citations

[1]Poland M, et al. Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. Biochim Biophys Acta. 2016 Dec;1861 (12 Pt A) :2020-2028.|[2]Wang Y, Balvers MGJ, Hendriks HFJ, Wilpshaar T, van Heek T, Witkamp RF, Meijerink J. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862 (9) :823-831.