Angiotensin II (1-4), human (TFA)
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE) . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney[1][2].
Product Specifications
UNSPSC
12352209
Target
Angiotensin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/angiotensin-ii-1-4-human-tfa.html
Solubility
H2O
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(O)=O)=O)=O)[C@H](CC(O)=O)N.OC(C(F)(F)F)=O
Molecular Formula
C26H38F3N7O10
Molecular Weight
665.62
References & Citations
[1]De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411.|[2]Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11 (2) :41-5.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Launched
Frequently Asked Questions
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