AG-1478
AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV) .
Product Specifications
CAS Number
153436-53-4
Product Name Alternative
Tyrphostin AG-1478; NSC 693255
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; HCV; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ag-1478.html
Purity
99.57
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC
Molecular Formula
C16H14ClN3O2
Molecular Weight
315.75
Precautions
H302, H315, H319, H335
References & Citations
[1]Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50 (2) :186-95.|[2]Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580.|[3]Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10 (7) :e0132215.|[4]Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60 (10) :6402-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
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