Duocarmycin TM
Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.
Product Specifications
CAS Number
[157922-77-5]
Product Name Alternative
CBI-TMI
UNSPSC
12352203
Target
ADC Payload; Antibiotic; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Duocarmycin_TM.html
Purity
99.82
Solubility
DMSO : ≥ 50 mg/mL
Smiles
ClC[C@H]1C2=C(C=CC=C3)C3=C(O)C=C2N(C(C4=CC(C=C(OC)C(OC)=C5OC)=C5N4)=O)C1
Molecular Formula
C25H23ClN2O5
Molecular Weight
466.91
References & Citations
[1]Zhang D, et, al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29 (2) :267-274.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Duocarmycins
Available Sizes
Curated Selection
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