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7-Chloro-4- (piperazin-1-yl) quinoline

7-Chloro-4- (piperazin-1-yl) quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4- (piperazin-1-yl) quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM) . 7-Chloro-4- (piperazin-1-yl) quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1].

Product Specifications

CAS Number

837-52-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite; Sirtuin

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/7-chloro-4-piperazin-1-yl-quinoline.html

Purity

98.63

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC2=C(C(N3CCNCC3)=CC=N2)C=C1

Molecular Formula

C13H14ClN3

Molecular Weight

247.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Aida M Abd El-Sattar El-Azzouny, et al. Structural and biological survey of 7-chloro-4- (piperazin-1-yl) quinoline and its derivatives. Drug Dev Res. 2020 Nov;81 (7) :786-802.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Plasmodium

Available Sizes

Frequently Asked Questions

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