7-Chloro-4-(piperazin-1-yl)quinoline
Product Specifications
UNSPSC Description
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1].
Target Antigen
Parasite; Sirtuin
Type
Reference compound
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/7-chloro-4-piperazin-1-yl-quinoline.html
Purity
98.63
Solubility
DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
ClC1=CC2=C(C(N3CCNCC3)=CC=N2)C=C1
Molecular Weight
247.729
References & Citations
[1]Aida M Abd El-Sattar El-Azzouny, et al. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug Dev Res. 2020 Nov;81(7):786-802.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W020111/7-Chloro-4-piperazin-1-yl-quinoline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W020111/7-Chloro-4-piperazin-1-yl-quinoline-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
837-52-5
Available Sizes
Curated Selection
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