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Dyclonine (hydrochloride) (Standard)

Dyclonine (hydrochloride) (Standard) is the analytical standard of Dyclonine (hydrochloride) . This product is intended for research and analytical applications. Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain[1][2][3].

Product Specifications

CAS Number

536-43-6

Product Name Alternative

Dyclocaine hydrochloride (Standard)

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH) ; Bacterial; Fungal; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/dyclonine-hydrochloride-standard.html

Smiles

O=C(C1=CC=C(OCCCC)C=C1)CCN2CCCCC2.Cl

Molecular Formula

C18H28ClNO2

Molecular Weight

325.87

References & Citations

[1]Okazaki S, et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018 Sep 18;9 (73) :33832-33843. |[2]FLORESTANO HJ, et al. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc. 1956 May;45 (5) :320-5. |[3]Khanna M, et al. Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. J Biol Chem. 2011 Dec 16;286 (50) :43486-94.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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