Benfluorex (hydrochloride)
Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
Product Specifications
CAS Number
23642-66-2
Product Name Alternative
JP-992 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Orphan Nuclear Receptor; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Benfluorex-hydrochloride.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL|H2O : 2.27 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C1=CC(CC(NCCOC(C2=CC=CC=C2)=O)C)=CC=C1)(F)F.[H]Cl
Molecular Formula
C19H21ClF3NO2
Molecular Weight
387.82
Precautions
H315, H319, H335
References & Citations
[1]Lee SH, et al. Identification of alverine and benfluorex as HNF4α activators. ACS Chem Biol. 2013 Aug 16;8 (8) :1730-6.|[2]Kohl C, et al. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Diabetes. 2002 Aug;51 (8) :2363-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Adv Sci (Weinh) . 2024 Jul 5:e2403451.|Virol J. 2021 Sep 28;18 (1) :196.|Biochem Pharmacol. 2022 Sep:203:115198.|EBioMedicine. 2022 Aug:82:104181.|Research Square Print. December 19th, 2022.
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