Benfluorex (hydrochloride)

Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.

Product Specifications

CAS Number

[23642-66-2]

Product Name Alternative

JP-992 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Orphan Nuclear Receptor; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Benfluorex-hydrochloride.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL|H2O : 2.27 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(C1=CC(CC(NCCOC(C2=CC=CC=C2)=O)C)=CC=C1)(F)F.[H]Cl

Molecular Formula

C19H21ClF3NO2

Molecular Weight

387.82

Precautions

H315, H319, H335

References & Citations

[1]Lee SH, et al. Identification of alverine and benfluorex as HNF4α activators. ACS Chem Biol. 2013 Aug 16;8 (8) :1730-6.|[2]Kohl C, et al. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Diabetes. 2002 Aug;51 (8) :2363-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Adv Sci (Weinh) . 2024 Jul 5:e2403451.|Virol J. 2021 Sep 28;18 (1) :196.|Biochem Pharmacol. 2022 Sep:203:115198.|EBioMedicine. 2022 Aug:82:104181.|Research Square Print. December 19th, 2022.