Veratridine (Standard)

Veratridine (Standard) is the analytical standard of Veratridine. This product is intended for research and analytical applications. Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39?μM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow[1][2].

Product Specifications

CAS Number

[71-62-5]

Product Name Alternative

3-Veratroylveracevine (Standard)

UNSPSC

12352005

Target

Reference Standards; Sodium Channel

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/veratridine-standard.html

Smiles

C[C@@]12[C@]34[C@](CC[C@]1([H])[C@@](O)([C@@H](OC(C5=CC(OC)=C(OC)C=C5)=O)CC2)O4)([H])[C@@]6(O)[C@](O)([C@@]7([H])[C@@](O)([C@](O)([C@@]8([H])N(C[C@@H](C)CC8)C7)C)[C@@H](O)C6)C3

Molecular Formula

C36H51NO11

Molecular Weight

673.79

References & Citations

[1]Zhang XY, et al. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39 (11) :1716-1724.|[2]Laura A Uribe, et al. Supramolecular Complexes of Plant Neurotoxin Veratridine with Cyclodextrins and Their Antidote-like Effect on Neuro-2a Cell Viability. Pharmaceutics. 2022 Mar 9;14 (3) :598.|[3]Zainab A Mohammed, et al. Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep. 2017 Mar 24;7:45221.