TP-1287
TP-1287, a prodrug of Alvocidib , is an orally active CDK9 inhibitor[1].
Product Specifications
CAS Number
2044686-42-0
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tp-1287.html
Purity
95.10
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : 125 mg/mL (ultrasonic)
Smiles
O=P(O)(O)OC1=CC(O)=C(C(C=C(C2=C(C=CC=C2)Cl)O3)=O)C3=C1[C@@H]4[C@@H](CN(CC4)C)O
Molecular Formula
C21H21ClNO8P
Molecular Weight
481.82
References & Citations
[1]Tyagi E, et al. The Oral CDK9 Inhibitor, TP-1287, Is Active in Non-Clinical Models of Multiple Myeloma. Blood, 2018, 132: 3269.|[2]Kim W, et al. TP-1287, an oral prodrug of the cyclin-dependent kinase-9 inhibitor alvocidib. Cancer Research, 2017, 77 (13_Supplement) : 5133-5133.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CDK9
Available Sizes
Frequently Asked Questions
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