Diprovocim
Diprovocim is a potent TLR1/TLR2 agonist. Diprovocim elicits full agonist activity in human THP-1 cells (EC50=110 pM) . Diprovocim stimulates the release of TNF-α from mouse macrophages (EC50=1.3 nM) . Diprovocim activates downstream MAPK and NF-κB signaling pathway. Diprovocim displays strong adjuvant activity in mice, particularly abetting cellular immune responses[1][2].
Product Specifications
CAS Number
2170867-89-5
UNSPSC
12352005
Target
NF-κB; p38 MAPK; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diprovocim.html
Purity
98.82
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
Molecular Formula
C56H56N6O6
Molecular Weight
909.08
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB; p38 MAPK; TLR1; TLR2
Available Sizes
Frequently Asked Questions
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