PF-4178903
PF-4178903 (INCB10820) is an orally active, potent dual CCR2 and CCR5 antagonist with IC50 values of 3 nM and 5.3 nM, respectively. PF-4178903 is promising for research of chronic inflammatory and autoimmune diseases[1].
Product Specifications
CAS Number
1310796-72-5
Product Name Alternative
INCB10820
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-4178903.html
Smiles
O=C(N1CCN(C2=CC(C(F)(F)F)=CC=N2)CC1)[C@@]3(C[C@@H](CC3)N[C@@H]4[C@@H](COCC4)OC)C(C)C
Molecular Formula
C25H37F3N4O3
Molecular Weight
498.58
References & Citations
[1]Zheng C, et al. Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist. Bioorg Med Chem Lett. 2011 Mar 1;21 (5) :1442-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2; CCR5
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