Pravastatin-d9 (sodium)
Pravastatin-d9 sodium is deuterated labeled Pravastatin. Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1].
Product Specifications
Product Name Alternative
CS-514-d9 (sodium)
UNSPSC
12352211
Target
Autophagy; HMG-CoA Reductase (HMGCR) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
[H][C@@]12C(C=C[C@H](C)[C@@H]2CC[C@](O)([H])C[C@@H](O)CC(O[Na])=O)=C[C@@H](O)C[C@@H]1OC([C@@]([2H])(C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])=O
Molecular Formula
C23H26D9NaO7
Molecular Weight
455.57
References & Citations
[1]McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42 (1) :65-89.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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