Quinine (hydrochloride dihydrate)

Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

Product Specifications

CAS Number

[6119-47-7]

UNSPSC

12352005

Hazard Statement

H302, H316, H317, H335

Target

Dengue Virus; Flavivirus; Parasite; Potassium Channel

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/quinine-hydrochloride-dihydrate.html

Concentration

10mM

Purity

99.68

Solubility

DMSO : ≥ 100 mg/mL|H2O : 20 mg/mL (ultrasonic)

Smiles

COC1=CC2=C(N=CC=C2[C@H]([C@@]3([H])[N@](C[C@@H]4C=C)CC[C@@]4([H])C3)O)C=C1.Cl.O.O

Molecular Formula

C20H29ClN2O4

Molecular Weight

396.91

Precautions

H302, H316, H317, H335

References & Citations

[1]White, N.J., et al., Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med, 1982. 73 (4) : p. 564-72.|[2]Shilu Malakar, et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.|[3]Jhanwar, Deepika, et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate. (2016) : 2636-2640.|[4] Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23 (1) :39-