Penicillic acid

Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8[1][2].

Product Specifications

CAS Number

[90-65-3]

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Antibiotic; Apoptosis; Bacterial; Caspase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/penicillic-acid.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C=C(C)C(/C(OC)=C/C(O)=O)=O

Molecular Formula

C8H10O4

Molecular Weight

170.16

Precautions

H302, H312, H332

References & Citations

[1]Sorenson WG, et al. Toxicity of penicillic acid for rat alveolar macrophages in vitro. Environ Res. 1986 Dec;41 (2) :505-13.|[2]Bando M, et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J Biol Chem. 2003 Feb 21;278 (8) :5786-93.