HAP-1

HAP-1 is a synovial-targeted transduction peptide. HAP-1 facilitates specific internalization of protein complexes into human and rabbit synovial cells. HAP-1 fused to an antimicrobial peptide, (KLAK) 2, to generate a proapoptotic peptide DP2[1].

Product Specifications

CAS Number

[329004-38-8]

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hap-1.html

Purity

99.08

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

Molecular Formula

C60H90N18O17

Molecular Weight

1335.47

References & Citations

[1]Mi Z, et al. Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol Ther. 2003 Aug;8 (2) :295-305.