J-1149
J-1149 is a potent ALK5 inhibitor, with an IC50 value of 0.017 μM. J-1149 also shows weak p38α MAP kinase inhibitory activity, with an IC50 value of 0.435 μM. J-1149 can be used for liver fibrosis research[1].
Product Specifications
CAS Number
2883580-95-6
UNSPSC
12352005
Target
P38 MAPK; TGF-β Receptor
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/j-1149.html
Solubility
10 mM in DMSO
Smiles
N[C@H](CC1=CC=CC=C1)C(NCC2=NC(C3=CC=CC(C)=N3)=C(C4=CN5C(C=C4)=NC=N5)N2)=O
Molecular Formula
C25H24N8O
Molecular Weight
452.51
References & Citations
[1]Meng YQ, et al. Synthesis and anti-liver fibrosis activity of imidazole and thiazole compounds containing amino acids. Eur J Med Chem. 2024 Mar 13;269:116311.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALK5; p38α
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