J-1149

J-1149 is a potent ALK5 inhibitor, with an IC50 value of 0.017 μM. J-1149 also shows weak p38α MAP kinase inhibitory activity, with an IC50 value of 0.435 μM. J-1149 can be used for liver fibrosis research[1].

Product Specifications

CAS Number

[2883580-95-6]

UNSPSC

12352005

Target

P38 MAPK; TGF-β Receptor

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/j-1149.html

Solubility

10 mM in DMSO

Smiles

N[C@H](CC1=CC=CC=C1)C(NCC2=NC(C3=CC=CC(C)=N3)=C(C4=CN5C(C=C4)=NC=N5)N2)=O

Molecular Formula

C25H24N8O

Molecular Weight

452.51

References & Citations

[1]Meng YQ, et al. Synthesis and anti-liver fibrosis activity of imidazole and thiazole compounds containing amino acids. Eur J Med Chem. 2024 Mar 13;269:116311.