FKB04

FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice) . FKB04 can be used in liver cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Telomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fkb04.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

BrC1=CC(/C=C/C(C2=C(C=C(C=C2O)OC)OC)=O)=CC=C1

Molecular Formula

C17H15BrO4

Molecular Weight

363.20

References & Citations

[1]Qiu YD, et al. Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells. Acta Pharmacol Sin. 2024 Jun;45 (6) :1276-1286.