QL-X-138
Product Specifications
UNSPSC Description
QL-X-138 is a potent and selective BTK/MNK dual kinase inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC50s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC50 of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies[1][2].
Target Antigen
Btk; Dengue virus; Flavivirus; MNK
Type
Reference compound
Related Pathways
Anti-infection;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ql-x-138.html
Purity
99.77
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
C=CC(NC1=CC(N2C(C=CC3=C2C4=CC(C5=CNN=C5)=CC=C4N=C3)=O)=CC=C1C)=O
Molecular Weight
421.45
References & Citations
[1]Wu H, et, al. Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 2016 Jan;30(1):173-81.|[2]Wispelaere M, et, al. Discovery of host-targeted covalent inhibitors of dengue virus. Antiviral Res. 2017 Mar;139:171-179.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124645/QL-X-138-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124645/QL-X-138-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1469988-63-3
Available Sizes
Curated Selection
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