Avenaciolide

Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation[1][2].

Product Specifications

CAS Number

[26057-70-5]

UNSPSC

12352005

Target

Bacterial; Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/avenaciolide.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCC[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])C(O1)=O

Molecular Formula

C15H22O4

Molecular Weight

266.33

References & Citations

[1]Castelo-Branco PA, et al. Synthesis and antifungal activity of aromatic bis-gamma-lactones analogous to avenaciolide. Chem Biodivers. 2007;4 (12) :2745-2754. |[2]McGivan JD, Chappell JB. Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. Biochem J. 1970;116 (4) :37P-38P.