Avenaciolide
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation[1][2].
Product Specifications
CAS Number
26057-70-5
UNSPSC
12352005
Target
Bacterial; Fungal
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/avenaciolide.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCC[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])C(O1)=O
Molecular Formula
C15H22O4
Molecular Weight
266.33
References & Citations
[1]Castelo-Branco PA, et al. Synthesis and antifungal activity of aromatic bis-gamma-lactones analogous to avenaciolide. Chem Biodivers. 2007;4 (12) :2745-2754. |[2]McGivan JD, Chappell JB. Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. Biochem J. 1970;116 (4) :37P-38P.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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