BMS-986141
BMS-98614 is an orally active, selective thrombin receptor protease-activated receptor-4 (PAR-4) antagonist with an IC50 value of 0.4 nM. BMS-98614 has excellent antithrombotic effect[1][2].
Product Specifications
CAS Number
1478711-48-6
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-986141.html
Purity
98.86
Solubility
DMF : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(C)C)C1=CC=C(C2=NC(COC3=C4C=C(C5=CN6C(SC(OC)=N6)=N5)OC4=CC(OC)=C3)=CS2)C=C1
Molecular Formula
C27H23N5O5S2
Molecular Weight
561.63
References & Citations
[1]E Scott Priestley, et al. Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4. J Med Chem. 2022 Jul 14;65 (13) :8843-8854.|[2]P Wong, et al. Favorable therapeutic index of an orally-active small-molecule antagonist of the platelet protease-activated receptor-4, BMS-986141, compared with the P2Y12 antagonist ticagrelor in cynomolgus monkeys. European Heart Journal, Volume 41, Issue Supplement_2, November 2020.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PAR4
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP323551L 1 mg
Histone H2A Bbd (H2AFB2) (NM_001017991) Human Recombinant Protein
Sign In for Pricing
View Details ![PSMA (FOLH1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1F5]](https://cdn.genprice.uk/products/937/68dd1b88061270361ea21650/imageurl/ta813986am.webp)
TA813986AM 100 µL
PSMA (FOLH1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1F5]
Sign In for Pricing
View Details ![PCSK9 Mouse Monoclonal Antibody [Clone ID: OTI4G9]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908c1a/imageurl/cf811839.webp)
BNC402698-500 1x 500 µL
PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein) (PMEPA1/2698), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details