Prednisone

Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus[1][2].

Product Specifications

CAS Number

[53-03-2]

Product Name Alternative

Dehydrocortisone

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology; Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/prednisone.html

Purity

99.86

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])C2=O)=O

Molecular Formula

C21H26O5

Molecular Weight

358.43

Precautions

H302, H315, H319, H335

References & Citations

[1]RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1 (4) :488-96.|[2][2]N Tomioka, et al. Effects of prednisolone on acute viral myocarditis in mice. J Am Coll Cardiol. 1986 Apr;7 (4) :868-72.|[3]Qianqian Li, et al. Metabolic Profiling Reveals an Abnormal Pattern of Serum Fatty Acids in MRL/lpr Mice Under Treatment With Prednisone. Front Pharmacol. 2020 Feb 25;11:115.