2-Deoxy-D-glucose
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1].
Product Specifications
CAS Number
154-17-6
Product Name Alternative
2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Hexokinase; HSV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-Deoxy-D-glucose.html
Purity
99.93
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
OC1O[C@@H]([C@@H](O)[C@H](O)C1)CO
Molecular Formula
C6H12O5
Molecular Weight
164.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005 Aug 1;65 (15) :7023-30.|[2]Ueyama A, et al. Nonradioisotope assay of glucose uptake activity in rat skeletal muscle using enzymatic measurement of 2-deoxyglucose 6-phosphate in vitro and in vivo. Biol Signals Recept. 2000 Sep-Oct;9 (5) :267-74.|[3]Miwa H, et al. Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose. Oncol Rep. 2013 May;29 (5) :2053-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
Isoform
HSV-1
Available Sizes
Frequently Asked Questions
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