2-Deoxy-D-glucose

2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1].

Product Specifications

CAS Number

[154-17-6]

Product Name Alternative

2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Hexokinase; HSV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-Deoxy-D-glucose.html

Purity

99.93

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

OC1O[C@@H]([C@@H](O)[C@H](O)C1)CO

Molecular Formula

C6H12O5

Molecular Weight

164.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005 Aug 1;65 (15) :7023-30.|[2]Ueyama A, et al. Nonradioisotope assay of glucose uptake activity in rat skeletal muscle using enzymatic measurement of 2-deoxyglucose 6-phosphate in vitro and in vivo. Biol Signals Recept. 2000 Sep-Oct;9 (5) :267-74.|[3]Miwa H, et al. Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose. Oncol Rep. 2013 May;29 (5) :2053-7.