Triclosan

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC) . Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].

Product Specifications

CAS Number

[3380-34-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H410

Target

Antibiotic; Apoptosis; Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Triclosan.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C) |Methanol : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl

Molecular Formula

C12H7Cl3O2

Molecular Weight

289.55

Precautions

H315, H319, H410

References & Citations

[1]R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274 (16) :11110-4.|[2]Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul) . 2016 Jan;24 (1) :99-107.|[3]Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13 (1) :136.