LpxC-IN-15

LpxC-IN-15 ((S) -13j) is a potent LpxC inhibitor with Ki values of 9.05, 5.6 nM for EcLpxC C63A, PaLpxC, respectively. LpxC-IN-15 shows antibacterial activity[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lpxc-in-15.html

Smiles

O=C(NO)[C@@H](OCC1=CC=C(C=C1)C#CC2=CC=C(C=C2)CN3CCOCC3)CNC(C4=CC(C=CN5)=C5C=C4)=O

Molecular Formula

C32H32N4O5

Molecular Weight

552.62

References & Citations

[1]Mielniczuk S, et al. Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity. J Med Chem. 2024 Oct 10;67 (19) :17363-17391.