LpxC-IN-15
LpxC-IN-15 ((S) -13j) is a potent LpxC inhibitor with Ki values of 9.05, 5.6 nM for EcLpxC C63A, PaLpxC, respectively. LpxC-IN-15 shows antibacterial activity[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lpxc-in-15.html
Smiles
O=C(NO)[C@@H](OCC1=CC=C(C=C1)C#CC2=CC=C(C=C2)CN3CCOCC3)CNC(C4=CC(C=CN5)=C5C=C4)=O
Molecular Formula
C32H32N4O5
Molecular Weight
552.62
References & Citations
[1]Mielniczuk S, et al. Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity. J Med Chem. 2024 Oct 10;67 (19) :17363-17391.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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