Sipeimine
Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases[1][2].
Product Specifications
CAS Number
61825-98-7
Product Name Alternative
Imperialine
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Akt; Ferroptosis; NF-κB; NOD-like Receptor (NLR) ; PI3K; Pyroptosis
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Sipeimine.html
Concentration
10mM
Purity
98.57
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@]([C@@]1([H])C2=O)(CC[C@H](O)C1)[C@]3([H])[C@](C2)([H])[C@@](CC[C@]4([H])[C@@]5([H])CN(C[C@@H](C)CC6)[C@]6([H])[C@]4(O)C)([H])[C@@]5([H])C3
Molecular Formula
C27H43NO3
Molecular Weight
429.64
Precautions
H302+H312+H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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