Sipeimine

Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases[1][2].

Product Specifications

CAS Number

[61825-98-7]

Product Name Alternative

Imperialine

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Akt; Ferroptosis; NF-κB; NOD-like Receptor (NLR) ; PI3K; Pyroptosis

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Sipeimine.html

Concentration

10mM

Purity

98.57

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]([C@@]1([H])C2=O)(CC[C@H](O)C1)[C@]3([H])[C@](C2)([H])[C@@](CC[C@]4([H])[C@@]5([H])CN(C[C@@H](C)CC6)[C@]6([H])[C@]4(O)C)([H])[C@@]5([H])C3

Molecular Formula

C27H43NO3

Molecular Weight

429.64

Precautions

H302+H312+H332

References & Citations

[1]Fang Y, et al. Sipeimine ameliorates osteoarthritis progression by suppression of NLRP3 inflammasome-mediated pyroptosis through inhibition of PI3K/AKT/NF-κB pathway: An in vitro and in vivo study. J Orthop Translat. 2024 May 9;46:1-17.|[2]Wang Y, et al. Sipeimine ameliorates PM2.5-induced lung injury by inhibiting ferroptosis via the PI3K/Akt/Nrf2 pathway: A network pharmacology approach. Ecotoxicol Environ Saf. 2022 Jul 1;239:113615.