Api137 (TFA)
Product Specifications
UNSPSC Description
Api137 TFA is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 TFA inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain[1][2].
Target Antigen
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/api137-tfa.html
Purity
98.96
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)[C@H]4N(CCC4)C([C@H](CCCNC(N)=N)NC([C@H]5N(CCC5)C([C@H](CCCNC(N)=N)NC([C@H]6N(CCC6)C([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC([C@H]7N(CCC7)C([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CCCN)/N=C(N(C)C)/N(C)C)=O)=O)=O)=O)=O)=O)CC8=CC=C(C=C8)O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]
Molecular Weight
2291.71 (free acid)
References & Citations
[1]Florin T, et, al. An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome. Nat Struct Mol Biol. 2017 Sep;24(9):752-757.|[2]Graf M, et, al. Intracellular Antimicrobial Peptides Targeting the Protein Synthesis Machinery. Adv Exp Med Biol. 2019:1117:73-89.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5723A/Api137-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5723A/Api137-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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