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Api137 (TFA)

Api137 TFA is an antimicrobial peptide that interferes with bacterial growth by inhibiting translation. Api137 TFA inhibits protein synthesis by trapping of release factors on the 70S ribosome following hydrolysis of the nascent polypeptide chain[1][2].

Product Specifications

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/api137-tfa.html

Purity

99.40

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)[C@H]4N(CCC4)C([C@H](CCCNC(N)=N)NC([C@H]5N(CCC5)C([C@H](CCCNC(N)=N)NC([C@H]6N(CCC6)C([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](C(C)C)NC([C@H]7N(CCC7)C([C@H](CCCNC(N)=N)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CCCN)/N=C(N(C)C)/N(C)C)=O)=O)=O)=O)=O)=O)CC8=CC=C(C=C8)O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C104H171N37O22.xC2HF3O2

Molecular Weight

2291.71 (free acid)

References & Citations

[1]Florin T, et, al. An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome. Nat Struct Mol Biol. 2017 Sep;24 (9) :752-757.|[2]Graf M, et, al. Intracellular Antimicrobial Peptides Targeting the Protein Synthesis Machinery. Adv Exp Med Biol. 2019:1117:73-89.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P5723A/Api137-TFA-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P5723A/Api137-TFA-SDS-MedChemExpress.pdf

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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