A-769662
A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 μM) . A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes[1][2][3][4].
Product Specifications
CAS Number
844499-71-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/A-769662.html
Purity
99.33
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
N#CC1C(C2=C(NC1=O)SC=C2C3=CC=C(C4=CC=CC=C4O)C=C3)=O
Molecular Formula
C20H12N2O3S
Molecular Weight
360.39
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK
Available Sizes
Frequently Asked Questions
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