Idalopirdine (hydrochloride)

Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders[1][2].

Product Specifications

CAS Number

[467458-02-2]

Product Name Alternative

Lu AE58054 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/idalopirdine-hydrochloride.html

Purity

99.64

Solubility

DMSO : ≥ 25 mg/mL|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC(NC=C2CCNCC3=CC(OCC(F)(F)C(F)F)=CC=C3)=C2C=C1.Cl

Molecular Formula

C20H20ClF5N2O

Molecular Weight

434.83

Precautions

H302

References & Citations

[1]Magdalena Kotańska, et al. Idalopirdine, a selective 5-HT6 receptor antagonist, reduces food intake and body weight in a model of excessive eating. Metab Brain Dis. 2018 Jun;33 (3) :733-740. |[2]Maria Amat-Foraster, et al. The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture. Neuropharmacology. 2017 Feb;113 (Pt A) :45-59.