PROTAC MPS1 degrader 2
PROTAC MPS1 degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC50s of 42.0, 2.1 and 154.0 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein ; Black: linker (HY-N0420) ; Blue: ligand for E3 ligase (HY-10984).
Product Specifications
UNSPSC
12352211
Target
Aurora Kinase; Mps1; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-mps1-degrader-2.html
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC(N4CCN(C5=CC=C(NC6=NC(NC7=CC=CC=C7S(=O)(C(C)C)=O)=C8N=CNC8=N6)C=C5)CC4)=O
Molecular Formula
C41H41N11O8S
Molecular Weight
847.90
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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