Lys-γ3-MSH(human) (TFA)
Product Specifications
UNSPSC Description
Lys-γ3-MSH(human) TFA is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) TFA potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) TFA is a potent stimulator of lipolysis with an apparent EC50 of 3.56 nM. Lys-γ3-MSH(human) TFA can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis[1][2].
Target Antigen
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/lys-γ3-msh-human-tfa.html
Purity
97.44
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC6=CC=CC=C6)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](C)C(NCC(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Molecular Weight
3018.25 (free acid)
References & Citations
[1]Harmer SC, Pepper DJ, Cooke K, Bennett HP, Bicknell AB. Evidence of a possible role for Lys-gamma3-MSH in the regulation of adipocyte function. J Endocrinol. 2008;196(1):149-158.|[2]Bicknell KA, et al. Lys-gamma3-MSH: a global regulator of hormone sensitive lipase activity? Mol Cell Endocrinol. 2009;300(1-2):71-76.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1210A/Lys-γ3-MSH-human-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1210A/Lys-γ3-MSH-human-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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