Human Eotaxin/CCL11 (Recombinant)

<strong>Human Eotaxin/CCL11</strong>_x000D_ <strong>Catalog number:</strong> B2010353_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Human Eotaxin/CCL11 expressed in E. coli. This protein acts as a potent chemoattractant for eosinophil cells and provides a new mechanism for tissue eosinophilia._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuEotaxin/CCL11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Mangieri D, Corradi D, Martorana D, Malerba G, Palmisano A, Libri I, Bartoli_x000D_ V, Carnevali ML, Goldoni M, Govoni P, Alinovi R, Buzio C, Vaglio A._x000D_ Eotaxin/CCL11 in idiopathic retroperitoneal fibrosis. Nephrol Dial Transplant._x000D_ 2012 Oct;27(10):3875-84._x000D_ _x000D_ 2: Cheng SS, Lukacs NW, Kunkel SL. Eotaxin/CCL11 is a negative regulator of_x000D_ neutrophil recruitment in a murine model of endotoxemia. Exp Mol Pathol. 2002_x000D_ Aug;73(1):1-8._x000D_ _x000D_ 3: Cheng SS, Lukacs NW, Kunkel SL. Eotaxin/CCL11 suppresses IL-8/CXCL8 secretion_x000D_ from human dermal microvascular endothelial cells. J Immunol. 2002 Mar_x000D_ 15;168(6):2887-94._x000D_ _x000D_ 4: Zweifel M, Matozan K, Dahinden C, Schaffner T, Mohacsi P. Eotaxin/CCL11_x000D_ levels correlate with myocardial fibrosis and mast cell density in native and_x000D_ transplanted rat hearts. Transplant Proc. 2010 Sep;42(7):2763-6._x000D_ _x000D_ 5: Pham TH, Damera G, Newbold P, Ranade K. Reductions in eosinophil biomarkers_x000D_ by benralizumab in patients with asthma. Respir Med. 2016 Feb;111:21-9._x000D_ _x000D_ 6: Zweifel M, Mueller C, Schaffner T, Dahinden C, Matozan K, Driscoll R, Mohacsi_x000D_ P. Eotaxin/CCL11 expression by infiltrating macrophages in rat heart transplants_x000D_ during ongoing acute rejection. Exp Mol Pathol. 2009 Oct;87(2):127-32._x000D_ _x000D_ 7: Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N. The_x000D_ CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung_x000D_ fibroblasts. J Allergy Clin Immunol. 2006 Jan;117(1):103-10._x000D_ _x000D_ 8: Schuh JM, Blease K, Kunkel SL, Hogaboam CM. Eotaxin/CCL11 is involved in_x000D_ acute, but not chronic, allergic airway responses to Aspergillus fumigatus. Am J_x000D_ Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L198-204._x000D_ _x000D_ 9: Panizzutti B, Gubert C, Schuh AL, Ferrari P, Bristot G, Fries GR, Massuda R,_x000D_ Walz J, Rocha NP, Berk M, Teixeira AL, Gama CS. Increased serum levels of_x000D_ eotaxin/CCL11 in late-stage patients with bipolar disorder: An accelerated aging_x000D_ biomarker? J Affect Disord. 2015 Aug 15;182:64-9._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/20143648/">10: Kohan M, Puxeddu I, Reich R, Levi-Schaffer F, Berkman N. Eotaxin-2/CCL24 and_x000D_ eotaxin-3/CCL26 exert differential profibrogenic effects on human lung_x000D_ fibroblasts. Ann Allergy Asthma Immunol. 2010 Jan;104(1):66-72. </a>_x000D_ _x000D_ <strong>Products Related to Human Eotaxin/CCL11 </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>