Thalidomide-O-PEG4-amine (hydrochloride)
Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Product Specifications
CAS Number
[2820929-03-9]
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-o-peg4-amine-hydrochloride.html
Purity
95.24
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCN)=O.[H]Cl
Molecular Formula
C23H32ClN3O9
Molecular Weight
529.97
References & Citations
[1]Zhang NN, et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020;182 (5) :1271-1283.e16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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