FASN-IN-4
FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29) [1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC50 of 18.6 nM[2].
Product Specifications
CAS Number
[1375105-96-6]
UNSPSC
12352005
Target
Fatty Acid Synthase (FASN) ; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/FAS-IN-1.html
Concentration
10mM
Purity
99.21
Solubility
10 mM in DMSO
Smiles
O=C1COC2(CCN(S(=O)(C3=CC=C(C4=CC=C5C=CC=NC5=C4)C=C3)=O)CC2)CN1C6CC6
Molecular Formula
C26H27N3O4S
Molecular Weight
477.58
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cell Biosci. 2022 Sep 16;12 (1) :158.|Nat Metab. 2021 Nov;3 (11) :1466-1475. |Sci China Life Sci. 2022 Feb;65 (2) :341-361.
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