FASN-IN-4

FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29) [1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC50 of 18.6 nM[2].

Product Specifications

CAS Number

[1375105-96-6]

UNSPSC

12352005

Target

Fatty Acid Synthase (FASN) ; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/FAS-IN-1.html

Concentration

10mM

Purity

99.21

Solubility

10 mM in DMSO

Smiles

O=C1COC2(CCN(S(=O)(C3=CC=C(C4=CC=C5C=CC=NC5=C4)C=C3)=O)CC2)CN1C6CC6

Molecular Formula

C26H27N3O4S

Molecular Weight

477.58

References & Citations

[1]Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.|[2]Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3 (11) :1466-1475.