FASN-IN-4
Product Specifications
UNSPSC Description
FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29)[1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC50 of 18.6?nM[2].
Target Antigen
Fatty Acid Synthase (FASN); SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/FAS-IN-1.html
Purity
99.21
Solubility
10 mM in DMSO
Smiles
O=C1COC2(CCN(S(=O)(C3=CC=C(C4=CC=C5C=CC=NC5=C4)C=C3)=O)CC2)CN1C6CC6
Molecular Weight
477.58
References & Citations
[1]Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.|[2]Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475.Cell Biosci. 2022 Sep 16;12(1):158.|Nat Metab. 2021 Sep 27;1-10.|Sci China Life Sci. 2021 May 27;1-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12648/FASN-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12648/FASN-IN-4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1375105-96-6
Available Sizes
Curated Selection
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