Polyinosinic-polycytidylic acid (sodium)
Polyinosinic-polycytidylic acid (Poly (I:C) ) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I) -like receptors (RIG-I and MDA5) . Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis[1][2].
Product Specifications
CAS Number
[42424-50-0]
Product Name Alternative
Poly (I:C) (sodium)
UNSPSC
12352211
Target
Apoptosis; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/polyinosinic-polycytidylic-acid-sodium.html
Purity
99.0
Solubility
H2O : 10 mg/mL (ultrasonic; warming)
Smiles
O[C@H]1[C@@H](O[C@H](COP(O)(O)=O)[C@H]1O)N2C3=C(C(NC=N3)=O)N=C2.O[C@H]4[C@H](N5C(N=C(N)C=C5)=O)O[C@H](COP(O)(O)=O)[C@H]4O.[x].[x].[Na].[x]
Molecular Formula
(C10H13N4O8P) x. (C9H14N3O8P) x.xNa
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR3
Citation 01
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Pseudomonas syringae pv. syringae Phosphoglycerate kinase (pgk)
Recombinant Pseudomonas syringae pv. syringae Phosphoglycerate kinase (pgk)