Salvinorin A

Salvinorin A is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A is a non-nitrogenous neoclerodane isolated from Salvia divinorum.

Product Specifications

CAS Number

[83729-01-5]

Product Name Alternative

Divinorin A

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/salvinorin-a.html

Purity

98.99

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]3([H])[C@]([C@@H](C[C@@H](C3=O)OC(C)=O)C(OC)=O)(CC[C@@]1([H])C(O[C@H](C4=COC=C4)C2)=O)C

Molecular Formula

C23H28O8

Molecular Weight

432.46

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Butelman ER, et al. Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol. 2015 Sep 8;6:190.|[2]John TF, et al. The antinociceptive effect of salvinorin A in mice.Eur J Pharmacol. 2006 Sep 18;545 (2-3) :129-33. Epub 2006 Jul 4.