GNE-131
GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.
Product Specifications
CAS Number
1629063-81-5
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GNE-131.html
Purity
98.15
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(NC1=NN=C2N1C=C(C3CC3)C(OCC45C[C@@H](C6)C[C@@H](C[C@@H]6C5)C4)=C2)(C7CC7)=O
Molecular Formula
C23H30N4O3S
Molecular Weight
442.57
References & Citations
[1]Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N- ([1,2,4]Triazolo[4,3- a]pyridin-3-yl) methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14;61 (11) :4810-4831.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7
Available Sizes
Frequently Asked Questions
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