GNE-131

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.

Product Specifications

CAS Number

[1629063-81-5]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/GNE-131.html

Purity

98.15

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(NC1=NN=C2N1C=C(C3CC3)C(OCC45C[C@@H](C6)C[C@@H](C[C@@H]6C5)C4)=C2)(C7CC7)=O

Molecular Formula

C23H30N4O3S

Molecular Weight

442.57

References & Citations

[1]Focken T, et al. Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N- ([1,2,4]Triazolo[4,3- a]pyridin-3-yl) methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem. 2018 Jun 14;61 (11) :4810-4831.