Naphthol AS-MX phosphate

Naphthol AS-MX phosphate (NASTRp) is a small molecule inhibitor of the CREB (cyclic adenosine phosphate reaction element binding protein) -CBP (CREB binding protein) transcription factor complex. Naphthol AS-MX phosphate shows antitumor activity against lung cancer cells, inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchored independent growth in soft AGAR. Naphthol AS-MX phosphate can be used in the study of KRAS mutated lung cancer, especially for KRAS mutated lung cancer with poor chemotherapy resistance and prognosis[1].

Product Specifications

CAS Number

[1596-56-1]

Product Name Alternative

NASTRp

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/naphthol-as-mx-phosphate.html

Purity

99.50

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=C(OP(O)(O)=O)C=C2C=CC=CC2=C1)NC3=CC=C(C)C=C3C

Molecular Formula

C19H18NO5P

Molecular Weight

371.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee J W, et al. A novel small-molecule inhibitor targeting CREB-CBP complex possesses anti-cancer effects along with cell cycle regulation, autophagy suppression and endoplasmic reticulum stress[J]. PLoS One, 2015, 10 (4) : e0122628.