Amino Tadalafil

Amino Tadalafil is a structural analogue of Tadalafil (HY-90009A) . Tadalafil is a potent inhibitor of PDE5 with applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction[1][2].

Product Specifications

CAS Number

[385769-84-6]

Product Name Alternative

D-APV; D-2-Amino-5-phosphonovaleric acid,L-APV; L-2-Amino-5-phosphonovaleric acid,2-APV (sodium); DL-2-Amino-5-phosphonovaleric acid (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/amino-tadalafil.html

Concentration

10mM

Purity

99.04

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(N)CC5=O

Molecular Formula

C21H18N4O4

Molecular Weight

390.39

Precautions

H302, H315, H319, H335

References & Citations

[1]D K Kim, et al. Synthesis and phosphodiesterase 5 inhibitory activity of new 5-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one derivatives containing an N-acylamido group phenyl ring. Bioorg Med Chem. 2001 Jul;9 (7) :1895-9.|[2]Hadwiger ME, et al. Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection. J Chromatogr A. 2010 Nov 26;1217 (48) :7547-55.