ML162-yne
ML162-yne is a potent GPX4-inhibitor affinity probe[1]. ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
2883115-46-4
UNSPSC
12352005
Hazard Statement
H302, H314
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml162-yne.html
Purity
99.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(N(C1=CC=C(C(Cl)=C1)OCC#C)C(CCl)=O)C2=CC=CS2)NCCC3=CC=CC=C3
Molecular Formula
C25H22Cl2N2O3S
Molecular Weight
501.42
Precautions
H302, H314
References & Citations
[1]Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020 May;16 (5) :497-506.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Sheep Olfactory receptor 8B8 (OR8B8) ELISA Kit
Sheep Olfactory receptor 8B8 (OR8B8) ELISA Kit